منابع مشابه
The evolving genetic risk for sporadic ALS.
OBJECTIVE To estimate the genetic risk conferred by known amyotrophic lateral sclerosis (ALS)-associated genes to the pathogenesis of sporadic ALS (SALS) using variant allele frequencies combined with predicted variant pathogenicity. METHODS Whole exome sequencing and repeat expansion PCR of C9orf72 and ATXN2 were performed on 87 patients of European ancestry with SALS seen at the University ...
متن کاملGenetic screening in sporadic ALS and FTD
The increasing complexity of the genetic landscape in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) presents a significant resource and physician training challenge. At least 10% of those diagnosed with ALS or FTD are known to carry an autosomal dominant genetic mutation. There is no consensus on what constitutes a positive family history, and ascertainment is unreliable...
متن کامل[Risk factors for sporadic cases of Campylobacter infection in children].
OBJECTIVES To identify risk factors for sporadic cases of Campylobacter infection in children aged 14 years. METHODS We performed an age-matched, case-control study. Cases were residents of Lleida Health Region aged 6 months to 14 years old with diarrhea and positive stool isolation for Campylobacter. Information was gathered by telephone using a structured questionnaire on individual suscept...
متن کاملSeroepidemiology and risk factors for sporadic norovirus/Mexico strain.
Risk factors associated with transmission of sporadic norovirus (NV; formerly Norwalk-like virus)/Mexico strain were identified in a seroepidemiological study conducted in rural Mexico. Acquisition of Mexico strain IgA antibodies was age-related; 34% of 1-4-year-olds were seropositive, compared with 81% of adults (P<.001). After 12 months, 42% of 1-4-year-olds showed a seroresponse to Mexico st...
متن کاملRisk factors for sporadic Yersinia enterocolitica infections, Germany 2009-2010.
Yersinia enterocolitica is an important cause of acute gastrointestinal disease and post-infectious complications. In Germany, incidence of reported yersiniosis is relatively high compared with other countries of the European Union. Children aged <5 years are most frequently affected. The aim of our study was to identify risk factors for sporadic yersiniosis in Germany. A population-based case-...
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ژورنال
عنوان ژورنال: Nature Reviews Neurology
سال: 2009
ISSN: 1759-4758,1759-4766
DOI: 10.1038/nrneurol.2009.172